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Relationship between tumour endothelial cell apoptosis and tumour blood flow shutdown following treatment with the antivascular agent DMXAA in mice

5,6-Dimethylxanthenone-4-acetic acid (DMXAA) is currently undergoing clinical evaluation as an antivascular agent for the treatment of cancer. We have previously demonstrated that DMXAA induces apoptosis of vascular endothelial cells in murine tumour sections and in a breast carcinoma biopsy from on...

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Bibliografiska uppgifter
Huvudupphovsmän: Ching, L-M, Zwain, S, Baguley, B C
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2004
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2410181/
https://ncbi.nlm.nih.gov/pubmed/14970872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6601606
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