Enhancement of the anti-tumour effects of the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) by combination with 5-hydroxytryptamine and bioreductive drugs.

The tumour blood flow inhibitor 5,6-dimethylxanthenone-4-acetic acid (DMXAA) causes dramatic haemorrhagic necrosis in murine tumours, but activity is seen only at doses close to the toxic limit. This study investigates two approaches for increasing the therapeutic ratio of DMXAA. The first approach...

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Main Authors: Lash, C. J., Li, A. E., Rutland, M., Baguley, B. C., Zwi, L. J., Wilson, W. R.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group|1 1998
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2063102/
https://ncbi.nlm.nih.gov/pubmed/9716024
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