Divergent Pathways in COS-7 Cells Mediate Defective Internalization and Intracellular Routing of Truncated G-CSFR Forms in SCN/AML

BACKGROUND: Expression of truncated G-CSFR forms in patients with SCN/AML induces hyperproliferation and prolonged cell survival. Previously, we showed that ligand internalization is delayed and degradation of truncated G-CSFR forms is defective in patients with SCN/AML. METHODOLOGY/PRINCIPAL FINDIN...

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Autores principales: Hunter, Melissa G., McLemore, Morgan, Link, Daniel C., Loveland, Megan, Copelan, Alexander, Avalos, Belinda R.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2008
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2409964/
https://ncbi.nlm.nih.gov/pubmed/18560579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002452
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