Phase I dose-escalation trial of irinotecan with continuous infusion 5-FU first line, in metastatic colorectal cancer

This single-centre phase I trial was designed to determine the maximum tolerated dose of irinotecan and the recommended dose to use in combination with a fixed dose of 5-fluorouracil (5-FU) administered as a protracted venous infusion, for the first-line treatment of metastatic colorectal cancer (CR...

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Detalhes bibliográficos
Main Authors: Saunders, M P, Hogg, M, Carrington, B, Sjursen, A-M, Allen, J, Beech, J, Swindell, R, Valle, J W
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2004
Assuntos:
Clinical
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2409945/
https://ncbi.nlm.nih.gov/pubmed/15452550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602173
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