Dose-finding study and pharmacogenomic analysis of fixed-rate infusion of gemcitabine, irinotecan and bevacizumab in pretreated metastatic colorectal cancer patients

BACKGROUND: To determine the dose-limiting toxicity (DLT), maximum tolerated dose, recommended dose (RD) and preliminary evidence of activity of escalating doses of irinotecan (CPT-11) fixed-dose-rate infusional gemcitabine (FDR-GMB) and bevacizumab in pretreated metastatic colorectal cancer (mCRC)...

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Bibliografiske detaljer
Main Authors: Abajo, A, Rodriguez, J, Bitarte, N, Zarate, R, Boni, V, Ponz, M, Chopitea, A, Bandres, E, Garcia-Foncillas, J
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2010
Fag:
Clinical Study
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2990573/
https://ncbi.nlm.nih.gov/pubmed/20940716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605908
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