Constitutional activation of IL-6-mediated JAK/STAT pathway through hypermethylation of SOCS-1 in human gastric cancer cell line

The interleukin-mediated Janus kinase (JAK)/STAT pathway plays a crucial role in carcinogenesis. Recently, increased STAT3 activity was found in hepatocellular carcinoma and multiple myeloma in which there was silencing of SOCS-1 (suppressor of cytokine signalling-1) by gene promoter hypermethylatio...

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Bibliografiska uppgifter
Huvudupphovsmän: To, K F, Chan, M W Y, Leung, W K, Ng, E K W, Yu, J, Bai, A H C, Lo, A W I, Chu, S H, Tong, J H M, Lo, K W, Sung, J J Y, Chan, F K L
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2004
Ämnen:
Molecular and Cellular Pathology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2409891/
https://ncbi.nlm.nih.gov/pubmed/15354212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602133
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