Absence of cyclin D2 expression is associated with promoter hypermethylation in gastric cancer

Expression of cyclin D2 is absent in 30–70% of gastric cancers. We investigated the role of promoter hypermethylation in the transcriptional silencing of cyclin D2 in five gastric cell lines and 47 primary gastric carcinomas. CpG island methylation status of the cyclin D2 gene was studied by methyla...

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Detalhes bibliográficos
Main Authors: Yu, J, Leung, W K, Ebert, M P A, Leong, R W L, Tse, P C H, Chan, M W Y, Bai, A H C, To, K F, Malfertheiner, P, Sung, J J Y
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2003
Assuntos:
Molecular and Cellular Pathology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2377112/
https://ncbi.nlm.nih.gov/pubmed/12771922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600940
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