Coordinate hypermethylation at specific genes in prostate carcinoma precedes LINE-1 hypomethylation

In prostate carcinoma (PCa) increased DNA methylation (‘hypermethylation’) occurs at specific genes such as GSTP1. Nevertheless, overall methylation can be decreased (‘hypomethylation’) because methylation of repetitive sequences like LINE-1 retrotransposons is diminished. We analysed DNA from 113 P...

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Detalhes bibliográficos
Main Authors: Florl, A R, Steinhoff, C, Müller, M, Seifert, H-H, Hader, C, Engers, R, Ackermann, R, Schulz, W A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2004
Assuntos:
Molecular and Cellular Pathology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2409889/
https://ncbi.nlm.nih.gov/pubmed/15292941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602030
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