Phase I and pharmacokinetic study of irinotecan in combination with R115777, a farnesyl protein transferase inhibitor

The aims of this study were to determine the maximum-tolerated dose (MTD), toxicity profile, and pharmacokinetics of irinotecan given with oral R115777 (tipifarnib), a farnesyl protein transferase inhibitor. Patients were treated with escalating doses of irinotecan with interval-modulated dosing of...

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Main Authors: Sparreboom, A, Kehrer, D F S, Mathijssen, R H J, Xie, R, de Jonge, M J A, de Bruijn, P, Planting, A S T, Eskens, F A L M, Verheij, C, de Heus, G, Klaren, A, Zhang, S, Verhaeghe, T, Palmer, P A, Verweij, J
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2004
Fag:
Clinical
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2409716/
https://ncbi.nlm.nih.gov/pubmed/15083177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6601732
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