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Two functionally distinct subsites for the binding of internal blockers to the pore of voltage-activated K(+) channels

Many blockers of Na(+) and K(+) channels act by blocking the pore from the intracellular side. For Shaker K(+) channels, such intracellular blockers vary in their functional effect on slow (C-type) inactivation: Some blockers interfere with C-type inactivation, whereas others do not. These functiona...

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Hlavní autoři: Baukrowitz, Thomas, Yellen, Gary
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences of the USA 1996
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC24097/
https://ncbi.nlm.nih.gov/pubmed/8917595
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