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Factors affecting pharmacokinetic variability of oral topotecan: a population analysis
The aim of this study was to characterise the pharmacokinetics of the anticancer agent topotecan, and explore the influence of patient covariates and interoccasion variability on drug disposition. Data were obtained from 190 patients who received the drug as a 30-min infusion (N=72) or orally (N=118...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2409552/ https://ncbi.nlm.nih.gov/pubmed/14735174 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6601469 |
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