A phase I study with MAG-camptothecin intravenously administered weekly for 3 weeks in a 4-week cycle in adult patients with solid tumours

In MAG-camptothecin (MAG-CPT), the topoisomerase inhibitor camptothecin is linked to a water-soluble polymer. Preclinical experiments showed enhanced antitumour efficacy and limited toxicity compared to camptothecin alone. Prior phase I trials guided the regimen used in this study. The objectives we...

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Detalhes bibliográficos
Main Authors: Wachters, F M, Groen, H J M, Maring, J G, Gietema, J A, Porro, M, Dumez, H, de Vries, E G E, van Oosterom, A T
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2004
Assuntos:
Clinical
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2409516/
https://ncbi.nlm.nih.gov/pubmed/15150611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6601811
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