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Induction of tetrasomy by human papillomavirus type 16 E7 protein is independent of pRb binding and disruption of differentiation

We have demonstrated previously that high-risk human papillomaviruses (HPVs) induce tetrasomy in low-grade squamous intraepithelial lesions of the cervix. In this study we show that the E6 and E7 genes of high-risk HPV-16, but not those of low-risk HPV-6, are independently able to induce tetrasomy w...

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Autori principali: Southern, S A, Lewis, M H, Herrington, C S
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2004
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2409454/
https://ncbi.nlm.nih.gov/pubmed/15138476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6601827
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