p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein.

The cell cycle regulatory tumor suppressor proteins p53 and pRB are targeted for inactivation by several tumor viruses, including the high-risk types of human papillomaviruses (HPVs) via interactions of the HPV E6 and E7 oncoproteins with p53 and pRB, respectively. p53 plays a central role in a sign...

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Bibliographische Detailangaben
Hauptverfasser: Slebos, R J, Lee, M H, Plunkett, B S, Kessis, T D, Williams, B O, Jacks, T, Hedrick, L, Kastan, M B, Cho, K R
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1994
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC43986/
https://ncbi.nlm.nih.gov/pubmed/8202487
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