Modulation of TNF-α-converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF-α production and facilitates viral entry

Severe acute respiratory syndrome coronavirus (SARS-CoV) is a high-risk infectious pathogen. In the proposed model of respiratory failure, SARS-CoV down-regulates its receptor, angiotensin-converting enzyme 2 (ACE2), but the mechanism involved is unknown. We found that the spike protein of SARS-CoV...

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Detalhes bibliográficos
Main Authors: Haga, Shiori, Yamamoto, Norio, Nakai-Murakami, Chikako, Osawa, Yoshiaki, Tokunaga, Kenzo, Sata, Tetsutaro, Yamamoto, Naoki, Sasazuki, Takehiko, Ishizaka, Yukihito
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2409424/
https://ncbi.nlm.nih.gov/pubmed/18490652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711241105
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