Differential Anti-APOBEC3G Activity of HIV-1 Vif Proteins Derived from Different Subtypes

Antiretroviral cytidine deaminase APOBEC3G, which is abundantly expressed in peripheral blood lymphocytes and macrophages, strongly protects these cells against HIV-1 infection. The HIV-1 Vif protein overcomes this antiviral effect by enhancing proteasome-mediated APOBEC3G degradation and is key for...

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Autori principali: Iwabu, Yukie, Kinomoto, Masanobu, Tatsumi, Masashi, Fujita, Hideaki, Shimura, Mari, Tanaka, Yoshitaka, Ishizaka, Yukihito, Nolan, David, Mallal, Simon, Sata, Tetsutaro, Tokunaga, Kenzo
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
Soggetti:
Microbiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975159/
https://ncbi.nlm.nih.gov/pubmed/20833716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.173286
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