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Direct internalization of cell-surface BST-2/tetherin by the HIV-1 accessory protein Vpu

The host transmembrane protein BST-2/tetherin is a powerful antiviral factor that blocks the production of enveloped viruses. The HIV-1 accessory protein Vpu inhibits the antiviral activity of BST-2; however, the degradation pathway by which Vpu downregulates BST-2 from the cell surface and the actu...

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Main Authors: Iwabu, Yukie, Fujita, Hideaki, Tanaka, Yoshitaka, Sata, Tetsutaro, Tokunaga, Kenzo
Formato: Artigo
Idioma:Inglês
Publicado: Landes Bioscience 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928321/
https://ncbi.nlm.nih.gov/pubmed/20798829
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