Hematopoietic prostaglandin D(2) synthase controls the onset and resolution of acute inflammation through PGD(2) and 15-deoxyΔ(12–14) PGJ(2)

Hematopoietic prostaglandin D(2) synthase (hPGD(2)S) metabolizes cyclooxygenase (COX)-derived PGH(2) to PGD(2) and 15-deoxyΔ(12–14) PGJ(2) (15d-PGJ(2)). Unlike COX, the role of hPGD(2)S in host defense is ambiguous. PGD(2) can be either pro- or antiinflammatory depending on disease etiology, whereas...

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Detalhes bibliográficos
Main Authors: Rajakariar, Ravindra, Hilliard, Mark, Lawrence, Toby, Trivedi, Seema, Colville-Nash, Paul, Bellingan, Geoff, Fitzgerald, Desmond, Yaqoob, Muhammad M., Gilroy, Derek W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2409252/
https://ncbi.nlm.nih.gov/pubmed/18077391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0707394104
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