Essential role for hematopoietic prostaglandin D2 synthase in the control of delayed type hypersensitivity

Hematopoietic prostaglandin D(2) synthase (hPGD(2)S) metabolizes cyclooxygenase-derived prostaglandin (PG) H(2) to PGD(2), which is dehydrated to cyclopentenone PGs, including 15-deoxy-Δ(12,14)-PGJ(2) (15d-PGJ(2)). PGD(2) acts through two receptors (DP1 and DP2/CRTH2), whereas 15d-PGJ(2) can activat...

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Detalhes bibliográficos
Main Authors: Trivedi, Seema G., Newson, Justine, Rajakariar, Ravindra, Jacques, Thomas S., Hannon, Robert, Kanaoka, Yoshihide, Eguchi, Naomi, Colville-Nash, Paul, Gilroy, Derek W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1458814/
https://ncbi.nlm.nih.gov/pubmed/16547141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0507175103
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