GABA(A)-current rundown of temporal lobe epilepsy is associated with repetitive activation of GABA(A) “phasic” receptors

A study was made of the “rundown” of GABA(A) receptors, microtransplanted to Xenopus oocytes from surgically resected brain tissues of patients afflicted with drug-resistant human mesial temporal lobe epilepsy (mTLE). Cell membranes, isolated from mTLE neocortex specimens, were injected into frog oo...

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Hauptverfasser: Palma, Eleonora, Roseti, Cristina, Maiolino, Francesca, Fucile, Sergio, Martinello, Katiuscia, Mazzuferi, Manuela, Aronica, Eleonora, Manfredi, Mario, Esposito, Vincenzo, Cantore, Gianpaolo, Miledi, Ricardo, Simonato, Michele, Eusebi, Fabrizio
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2007
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2409246/
https://ncbi.nlm.nih.gov/pubmed/18083839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0710522105
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