Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk

Loss of imprinting (LOI) of the insulin-like growth factor-II gene (IGF2), leading to abnormal activation of the normally silent maternal allele, is a common human epigenetic population variant associated with a 5-fold increased frequency of colorectal neoplasia. Here, we show first that LOI leads s...

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Bibliografiske detaljer
Main Authors: Kaneda, Atsushi, Wang, Chiaochun J., Cheong, Raymond, Timp, Winston, Onyango, Patrick, Wen, Bo, Iacobuzio-Donahue, Christine A., Ohlsson, Rolf, Andraos, Rita, Pearson, Mark A., Sharov, Alexei A., Longo, Dan L., Ko, Minoru S. H., Levchenko, Andre, Feinberg, Andrew P.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2007
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2409243/
https://ncbi.nlm.nih.gov/pubmed/18087038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0710359105
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