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A loss of epigenetic control can promote cell death through reversing the balance of pathways in a signaling network

Epigenetic control of regulatory networks is only partially understood. Expression of Insulin-like growth factor-II (IGF2) is controlled by genomic imprinting, mediated by silencing of the maternal allele. Loss of imprinting of IGF2 (LOI) is linked to intestinal and colorectal cancers, causally in m...

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Publicado en:Mol Cell
Autores principales: Vanaja, Kiran G., Timp, Winston, Feinberg, Andrew, Levchenko, Andre
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6219618/
https://ncbi.nlm.nih.gov/pubmed/30244832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.08.025
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