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A loss of epigenetic control can promote cell death through reversing the balance of pathways in a signaling network
Epigenetic control of regulatory networks is only partially understood. Expression of Insulin-like growth factor-II (IGF2) is controlled by genomic imprinting, mediated by silencing of the maternal allele. Loss of imprinting of IGF2 (LOI) is linked to intestinal and colorectal cancers, causally in m...
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| Udgivet i: | Mol Cell |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6219618/ https://ncbi.nlm.nih.gov/pubmed/30244832 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.08.025 |
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