Regulation of p53 tetramerization and nuclear export by ARC

Inactivation of the transcription factor p53 is central to carcinogenesis. Yet only approximately one-half of cancers have p53 loss-of-function mutations. Here, we demonstrate a mechanism for p53 inactivation by apoptosis repressor with caspase recruitment domain (ARC), a protein induced in multiple...

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Hauptverfasser: Foo, Roger S.-Y., Nam, Young-Jae, Ostreicher, Marc Jason, Metzl, Mark D., Whelan, Russell S., Peng, Chang-Fu, Ashton, Anthony W., Fu, Weimin, Mani, Kartik, Chin, Suet-Feung, Provenzano, Elena, Ellis, Ian, Figg, Nichola, Pinder, Sarah, Bennett, Martin R., Caldas, Carlos, Kitsis, Richard N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2007
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2409226/
https://ncbi.nlm.nih.gov/pubmed/18087040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0710017104
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