Retinoblastoma protein and simian virus 40-dependent immortalization of human fibroblasts.

Transformation and immortalization of human diploid fibroblasts by simian virus 40 (SV40) is at least a two-stage process, since transformants have a limited lifespan in culture. We have isolated immortalized derivatives (AR5 and HAL) from transformants generated with an origin-defective SV40 genome...

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Bibliographic Details
Main Authors: Resnick-Silverman, L, Pang, Z, Li, G, Jha, K K, Ozer, H L
Format: Artigo
Language:Inglês
Published: 1991
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC240907/
https://ncbi.nlm.nih.gov/pubmed/1851857
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