Retinoblastoma protein and simian virus 40-dependent immortalization of human fibroblasts.

Transformation and immortalization of human diploid fibroblasts by simian virus 40 (SV40) is at least a two-stage process, since transformants have a limited lifespan in culture. We have isolated immortalized derivatives (AR5 and HAL) from transformants generated with an origin-defective SV40 genome...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Resnick-Silverman, L, Pang, Z, Li, G, Jha, K K, Ozer, H L
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1991
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC240907/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1851857/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.65.6.2845-2852.1991
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