Cytosolic Phospholipase A(2)-α Is Necessary for Platelet-activating Factor Biosynthesis, Efficient Neutrophil-mediated Bacterial Killing, and the Innate Immune Response to Pulmonary Infection: cPLA(2)-α DOES NOT REGULATE NEUTROPHIL NADPH OXIDASE ACTIVITY

The role of a cytosolic phospholipase A(2)-α (cPLA(2)-α) in neutrophil arachidonic acid release, platelet-activating factor (PAF) biosynthesis, NADPH oxidase activation, and bacterial killing in vitro, and the innate immune response to bacterial infection in vivo was examined. cPLA(2)-α activity was...

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Auteurs principaux: Rubin, Barry B., Downey, Gregory P., Koh, Adeline, Degousee, Norbert, Ghomashchi, Farideh, Nallan, Laxman, Stefanski, Eva, Harkin, Denis W., Sun, ChunXiang, Smart, Brian P., Lindsay, Thomas F., Cherepanov, Vera, Vachon, Eric, Kelvin, David, Sadilek, Martin, Brown, Glenn E., Yaffe, Michael B., Plumb, Jonathan, Grinstein, Sergio, Glogauer, Michael, Gelb, Michael H.
Format: Artigo
Langue:Inglês
Publié: 2004
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2409062/
https://ncbi.nlm.nih.gov/pubmed/15475363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M407438200
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