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Spindle Pole Regulation by a Discrete Eg5-Interacting Domain in TPX2
Targeting protein for Xklp2 (TPX2) activates the Ser/Thr-kinase Aurora A in mitosis and targets it to the mitotic spindle [1, 2]. These effects on Aurora A are mediated by the N-terminal domain of TPX2, whereas a C-terminal fragment has been reported to affect microtubule nucleation [3]. Using the X...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2408861/ https://ncbi.nlm.nih.gov/pubmed/18372177 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2008.02.077 |
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