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Phosphorylation of p53 Is Regulated by TPX2-Aurora A in Xenopus Oocytes
p53 is an important tumor suppressor regulating the cell cycle at multiple stages in higher vertebrates. The p53 gene is frequently deleted or mutated in human cancers, resulting in loss of p53 activity. This leads to centrosome amplification, aneuploidy, and tumorigenesis, three phenotypes also obs...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2645813/ https://ncbi.nlm.nih.gov/pubmed/19121998 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805959200 |
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