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Phosphorylation of p53 Is Regulated by TPX2-Aurora A in Xenopus Oocytes

p53 is an important tumor suppressor regulating the cell cycle at multiple stages in higher vertebrates. The p53 gene is frequently deleted or mutated in human cancers, resulting in loss of p53 activity. This leads to centrosome amplification, aneuploidy, and tumorigenesis, three phenotypes also obs...

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Bibliografski detalji
Glavni autori: Pascreau, Gaetan, Eckerdt, Frank, Lewellyn, Andrea L., Prigent, Claude, Maller, James L.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2645813/
https://ncbi.nlm.nih.gov/pubmed/19121998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805959200
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