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Synthesis, Physicochemical Properties and In Vitro Cytotoxicity of Nicotinic Acid Ester Prodrugs Intended for Pulmonary Delivery Using Perfluorooctyl Bromide as Vehicle
This study explores perfluorooctyl bromide (PFOB) as a potential vehicle for the pulmonary delivery of a series of prodrugs of nicotinic acid using cell culture studies. The prodrugs investigated have PFOB-water (log K(p) = 0.78 to > 2.2), perfluoromethylcyclohexane-toluene (log K(p) = −2.62 to 0...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2408535/ https://ncbi.nlm.nih.gov/pubmed/18164563 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpharm.2007.11.011 |
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