Synthesis, Physicochemical Properties and In Vitro Cytotoxicity of Nicotinic Acid Ester Prodrugs Intended for Pulmonary Delivery Using Perfluorooctyl Bromide as Vehicle

This study explores perfluorooctyl bromide (PFOB) as a potential vehicle for the pulmonary delivery of a series of prodrugs of nicotinic acid using cell culture studies. The prodrugs investigated have PFOB-water (log K(p) = 0.78 to > 2.2), perfluoromethylcyclohexane-toluene (log K(p) = −2.62 to 0...

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Autori principali: Lehmler, Hans-Joachim, Xu, Ling, Vyas, Sandhya M., Ojogun, Vivian A., Knutson, Barbara L., Ludewig, Gabriele
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2408535/
https://ncbi.nlm.nih.gov/pubmed/18164563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpharm.2007.11.011
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