In vitro resolution of adeno-associated virus DNA hairpin termini by wild-type Rep protein is inhibited by a dominant-negative mutant of rep.

An adeno-associated virus (AAV) genome with a Lys-to-His (K340H) mutation in the consensus nucleotide triphosphate binding site of the rep gene has a dominant-negative DNA replication phenotype in vivo. We expressed both wild-type (Rep78) and mutant (Rep78NTP) proteins in two helper-free expression...

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Publicado en:	J Virol
Autores principales:	Owens, R A, Carter, B J
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 1992
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC240835/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1309900/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.66.2.1236-1240.1992
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