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Negative regulation of the adeno-associated virus (AAV) P5 promoter involves both the P5 rep binding site and the consensus ATP-binding motif of the AAV Rep68 protein.

Transcript levels from the P5 promoter of adeno-associated virus type 2 (AAV) are negatively regulated by the AAV Rep78 and Rep68 proteins in the absence of helper virus. We have identified a Rep-responsive negative cis element of the P5 promoter between the P5 TATA box and transcription start site...

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Библиографические подробности
Главные авторы: Kyöstiö, S R, Wonderling, R S, Owens, R A
Формат: Artigo
Язык:Inglês
Опубликовано: 1995
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC189590/
https://ncbi.nlm.nih.gov/pubmed/7474090
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