Defects in Moloney murine leukemia virus replication caused by a reverse transcriptase mutation modeled on the structure of Escherichia coli RNase H.

We have studied a mutant Moloney murine leukemia virus with a deletion in reverse transcriptase (RT) which is predicted to make its RNase H domain resemble structurally that of human immunodeficiency virus RT. This deletion was based on improved RNase H homology alignments made possible by the recen...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Telesnitsky, A, Blain, S W, Goff, S P
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1992
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC240759/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1370551/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.66.2.615-622.1992
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