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Adaptive mutation: General mutagenesis is not a programmed response to stress but results from rare coamplification of dinB with lac
In a particular genetic system, selection stimulates reversion of a lac mutation and causes genome-wide mutagenesis (adaptive mutation). Selection allows rare plated cells with a duplication of the leaky lac allele to initiate clones within which further lac amplification improves growth rate. Growt...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC240707/ https://ncbi.nlm.nih.gov/pubmed/14559967 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1735464100 |
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