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Selection-Enhanced Mutagenesis of lac Genes Is Due to Their Coamplification with dinB Encoding an Error-Prone DNA Polymerase
To test whether growth limitation induces mutations, Cairns and Foster constructed an Escherichia coli strain whose mutant lac allele provides 1–2% of normal ability to use lactose. This strain cannot grow on lactose, but produces ∼50 Lac(+) revertant colonies per 10(8) plated cells over 5 days. Abo...
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| I publikationen: | Genetics |
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| Huvudupphovsmän: | , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Genetics Society of America
2018
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5844319/ https://ncbi.nlm.nih.gov/pubmed/29301907 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.117.300409 |
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