Large-Scale Mutagenesis in p19(ARF)- and p53-Deficient Mice Identifies Cancer Genes and Their Collaborative Networks

p53 and p19(ARF) are tumor suppressors frequently mutated in human tumors. In a high-throughput screen in mice for mutations collaborating with either p53 or p19(ARF) deficiency, we identified 10,806 retroviral insertion sites, implicating over 300 loci in tumorigenesis. This dataset reveals 20 gene...

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Hlavní autoři: Uren, Anthony G., Kool, Jaap, Matentzoglu, Konstantin, de Ridder, Jeroen, Mattison, Jenny, van Uitert, Miranda, Lagcher, Wendy, Sie, Daoud, Tanger, Ellen, Cox, Tony, Reinders, Marcel, Hubbard, Tim J., Rogers, Jane, Jonkers, Jos, Wessels, Lodewyk, Adams, David J., van Lohuizen, Maarten, Berns, Anton
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2405818/
https://ncbi.nlm.nih.gov/pubmed/18485879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.03.021
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