Amplification of human papillomavirus genomes in vitro is dependent on epithelial differentiation.

Human papillomaviruses (HPVs) infect squamous epithelium and establish their genomes as episomes in proliferating basal cells. As infected cells differentiate, the viral DNA is amplified to high copy number and infectious virus is produced. Viral production has not yet been observed in vitro due to...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Bedell, M A, Hudson, J B, Golub, T R, Turyk, M E, Hosken, M, Wilbanks, G D, Laimins, L A
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1991
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC240574/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1850010/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.65.5.2254-2260.1991
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