Amplification of human papillomavirus genomes in vitro is dependent on epithelial differentiation.

Human papillomaviruses (HPVs) infect squamous epithelium and establish their genomes as episomes in proliferating basal cells. As infected cells differentiate, the viral DNA is amplified to high copy number and infectious virus is produced. Viral production has not yet been observed in vitro due to...

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Bibliographic Details
Main Authors: Bedell, M A, Hudson, J B, Golub, T R, Turyk, M E, Hosken, M, Wilbanks, G D, Laimins, L A
Format: Artigo
Language:Inglês
Published: 1991
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC240574/
https://ncbi.nlm.nih.gov/pubmed/1850010
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