Amplification of human papillomavirus genomes in vitro is dependent on epithelial differentiation.

Human papillomaviruses (HPVs) infect squamous epithelium and establish their genomes as episomes in proliferating basal cells. As infected cells differentiate, the viral DNA is amplified to high copy number and infectious virus is produced. Viral production has not yet been observed in vitro due to...

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Bedell, M A, Hudson, J B, Golub, T R, Turyk, M E, Hosken, M, Wilbanks, G D, Laimins, L A
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 1991
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC240574/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1850010/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.65.5.2254-2260.1991
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