Conformational epitope on gp120 important in CD4 binding and human immunodeficiency virus type 1 neutralization identified by a human monoclonal antibody.

A human monoclonal antibody designated 15e is reactive with the envelope glycoprotein (gp120) of multiple isolates of human immunodeficiency virus type 1 (HIV-1). Antibody 15e also neutralizes HIV-1 with broad specificity and blocks gp120 binding to CD4. Characterization of the 15e epitope shows tha...

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Pubblicato in:	J Virol
Autori principali:	Ho, D D, McKeating, J A, Li, X L, Moudgil, T, Daar, E S, Sun, N C, Robinson, J E
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1991
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC240544/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1702163/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.65.1.489-493.1991
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