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Mutagenesis of the Glu-89 residue in human immunodeficiency virus type 1 (HIV-1) and HIV-2 reverse transcriptases: effects on nucleoside analog resistance.

A Glu-89-->Gly alteration in the human immunodeficiency virus type 1 reverse transcriptase (RT) was previously shown to result in resistance to several dideoxynucleoside analogs and to phosphonoformic acid (PFA; foscarnet). This residue was altered to Ala, Val, Ser, Thr, Gln, Asp, Asn, or Lys, and t...

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Udgivet i:J Virol
Principais autores: Song, Q, Yang, G, Goff, S P, Prasad, V R
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1992
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC240471/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1279207/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.66.12.7568-7571.1992
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