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Requirement of active human immunodeficiency virus type 1 integrase enzyme for productive infection of human T-lymphoid cells.

The human immunodeficiency virus type 1 (HIV-1) integrase enzyme exhibits significant amino acid sequence conservation with integrase proteins of other retroviruses. We introduced specific amino acid substitutions at a number of the conserved residue positions of recombinant HIV-1 integrase. Some of...

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Published in:J Virol
Main Authors: LaFemina, R L, Schneider, C L, Robbins, H L, Callahan, P L, LeGrow, K, Roth, E, Schleif, W A, Emini, E A
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 1992
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC240448/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1433523/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.66.12.7414-7419.1992
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