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Mutation of a cysteine residue in polyomavirus middle T antigen abolishes interactions with protein phosphatase 2A, pp60c-src, and phosphatidylinositol-3 kinase, activation of c-fos expression, and cellular transformation.

Polyomavirus middle T antigen (MT) interacts with several cellular proteins involved in cell proliferation. MT forms complexes with protein phosphatase 2A (PP2A), pp60c-src (and the related kinases c-fyn and c-yes), and phosphatidylinositol-3 kinase. We made a single point mutation in MT, changing a...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Glenn, G M, Eckhart, W
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1993
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC240262/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7680388/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.67.4.1945-1952.1993
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