High-frequency recombination mediated by polyomavirus large T antigen defective in replication.

We investigated the mechanism by which the large T antigen (T-Ag) of both polyomavirus and simian virus 40 (SV40) promotes homologous recombination in mammalian cells. To this end, we constructed a rat cell line, designated Hy5, that carries two mutated copies of the polyomavirus middle-T-Ag (pmt) o...

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Pubblicato in:	J Virol
Autori principali:	St-Onge, L, Bouchard, L, Bastin, M
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1993
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC240224/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8445711/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.67.4.1788-1795.1993
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