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High-frequency recombination mediated by polyomavirus large T antigen defective in replication.

We investigated the mechanism by which the large T antigen (T-Ag) of both polyomavirus and simian virus 40 (SV40) promotes homologous recombination in mammalian cells. To this end, we constructed a rat cell line, designated Hy5, that carries two mutated copies of the polyomavirus middle-T-Ag (pmt) o...

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Main Authors: St-Onge, L, Bouchard, L, Bastin, M
Formato: Artigo
Idioma:Inglês
Publicado: 1993
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC240224/
https://ncbi.nlm.nih.gov/pubmed/8445711
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