Herpes simplex virus type 1 dUTPase mutants are attenuated for neurovirulence, neuroinvasiveness, and reactivation from latency.

Herpes simplex virus type 1 (HSV-1) encodes a dUTPase which has been shown to be dispensable for normal viral replication in cultured cells (S. J. Caradonna and Y. Cheng, J. Biol. Chem. 256:9834-9837, 1981; F. B. Fisher and V. G. Preston, Virology 148:190-197, 1986). However, the importance of this...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Pyles, R B, Sawtell, N M, Thompson, R L
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC240166/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1328686/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.66.11.6706-6713.1992
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