Preclinical Toxicology of rQNestin34.5v.2: An Oncolytic Herpes Virus with Transcriptional Regulation of the ICP34.5 Neurovirulence Gene

rQNestin34.5v.2 is an oncolytic herpes simplex virus 1 (oHSV) that retains expression of the neurovirulent ICP34.5 gene under glioma-selective transcriptional regulation. To prepare an investigational new drug (IND) application, we performed toxicology and efficacy studies of rQNestin34.5v.2 in mice...

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Principais autores:	E. Antonio Chiocca, Hiroshi Nakashima, Kazue Kasai, Soledad A. Fernandez, Michael Oglesbee
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2020-06-01
coleção:	Molecular Therapy: Methods & Clinical Development
Assuntos:	herpes simplex virus ICP34.5 nestin, oncolytic virus, toxicology, glioblastoma, brain tumor, preclinical study
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2329050120300589
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