Dextran sulfate blocks antibody binding to the principal neutralizing domain of human immunodeficiency virus type 1 without interfering with gp120-CD4 interactions.

The mechanism of the antiviral activity of sulfated polysaccharides on human immunodeficiency virus type 1 (HIV-1) was investigated by determining the effect of dextran sulfate on the binding of CD4 and several anti-gp120 monoclonal antibodies to both recombinant and cell surface gp120. Dextran sulf...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Callahan, L N, Phelan, M, Mallinson, M, Norcross, M A
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1991
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC239935/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1995952/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.65.3.1543-1550.1991
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