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TGF-β–dependent suppressive function of Tregs requires wild-type levels of CD18 in a mouse model of psoriasis
Dysfunctional Tregs have been identified in individuals with psoriasis. However, their role in the pathogenesis of the disease remains unclear. Here we explored the effect of diminished CD18 (β(2) integrin) expression on the function of CD4(+)CD25(+)CD127(–) Tregs using the Cd18 hypomorphic (Cd18(hy...
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| 主要な著者: | , , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Clinical Investigation
2008
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2398739/ https://ncbi.nlm.nih.gov/pubmed/18521187 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI34916 |
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