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TGF-β–dependent suppressive function of Tregs requires wild-type levels of CD18 in a mouse model of psoriasis

Dysfunctional Tregs have been identified in individuals with psoriasis. However, their role in the pathogenesis of the disease remains unclear. Here we explored the effect of diminished CD18 (β(2) integrin) expression on the function of CD4(+)CD25(+)CD127(–) Tregs using the Cd18 hypomorphic (Cd18(hy...

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主要な著者: Wang, Honglin, Peters, Thorsten, Sindrilaru, Anca, Kess, Daniel, Oreshkova, Tsvetelina, Yu, Xue-Zhong, Seier, Anne Maria, Schreiber, Heike, Wlaschek, Meinhard, Blakytny, Robert, Röhrbein, Jan, Schulz, Guido, Weiss, Johannes M., Scharffetter-Kochanek, Karin
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Clinical Investigation 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2398739/
https://ncbi.nlm.nih.gov/pubmed/18521187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI34916
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